- Title
- Monotherapy of RAAS blockers and mobilization of aldosterone: a mechanistic perspective study in kidney disease
- Creator
- Gupta, Gaurav; Dahiya, Rajiv; Singh, Yogendra; Mishra, Anurag; Verma, Aseem; Gothwal, Sunil Kumar; Aljabali, Alaa A. A.; Dureja, Harish; Prasher, Parteek; Negi, Poonam; Kapoor, Deepak N.; Goyal, Rohit; Tambuwala, Murtaza M.; Chellappan, Dinesh K.; Dua, Kamal
- Relation
- Chemico-Biological Interactions Vol. 317, Issue 1 February 2020, no. 108975
- Publisher Link
- http://dx.doi.org/10.1016/j.cbi.2020.108975
- Publisher
- Elsevier Ireland
- Resource Type
- journal article
- Date
- 2020
- Description
- In patients with acute kidney injury progressively converting into chronic kidney disease (CKD), proteinuria and high blood pressure predict progression to end-stage renal disease (ESRD). Although, Renin-angiotensin-aldosterone system (RAAS) regulates blood pressure and kidney disease through both direct and indirect mechanisms. RAAS blockers that act at the level of angiotensin or lower in the cascade can cause compensatory increases in the plasma renin and angiotensin II level. Here, in this review article, we are exploring the evidence-based on RAAS blockade action releases of aldosterone and hypothesizing the molecular mechanism for converting the acute kidney injury into chronic kidney disease to end-stage renal disease.
- Subject
- renin-angiotensin-aldosterone system; chronic kidney disease; aldosterone synthase; angiotensin receptor blockers; angiotensin-converting enzyme inhibitors; hyperkalemia; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1463011
- Identifier
- uon:46616
- Identifier
- ISSN:0009-2797
- Language
- eng
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